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KMID : 0605620110180040254
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Journal of Korean Society of Biological Psychiatry
2011 Volume.18 No. 4 p.254 ~ p.259
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Right Caudate Volumetric Differences in Young Healthy Adults with Different Dopamine DRD2/ANKK1 Taq 1a Polymorphisms
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Jeon Yu-Jin
Choi Ye-Ra
Kim Ji-Hyun
Jung Ji-Young
Kim Da-Jung
Yu Suk-Gyeong
Im Joo-Yeon
Lee Jung-Hyun
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Abstract
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Objectives: The aim of this study was to assess variations in caudate volume according to dopamin receptor D2/ankyin repeat and kinase domain containing 1 (DRD2/ANKK1) Taq 1a polymorphisms in young healthy adults and to evaluate the relationship between caudate volumes and psychiatric symptoms as measured by the Brief Psychiatric Rating Scale.
Methods: Genetic information regarding DRD2/ANKK1 Taq 1a and T1-weighted brain magnetic resonance images were acquired from 30 young healthy adults. Automatic segmentation of caudate was performed using the FreeSurfer program.
Results: Individuals with A2 homozygotes of DRD2/ANKK1 Taq 1a polymorphisms (n = 10) had greater right caudate volumes compared to those with A1 allele (s)(18.4% greater ; p = 0.019). Right caudate volumes were negatively associated with total scores of the Brief Psychiatric Rating Scale (beta=-0.50 ; p = 0.016).
Conclusion: Our findings suggest the possibility that DRD2/ANKK1 Taq 1a polymorphisms may underlie the psychiatric symptoms by influencing the structure of the right caudate.
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KEYWORD
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DRD2/ANKK1 Taq 1a polymorphism, Caudate, Brief psychiatric rating scale, Magnetic resonance imaging
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